Causes of Type 2 Diabetes: People with obesity have a higher risk of diabetes than others. This claim is being made by American scientists. You can understand this relationship between obesity and diabetes in detail in this article.
American scientists have discovered in a new study how obesity increases the risk of type 2 diabetes. This research has been done by the California-Los Angeles team, which is trying to understand the relationship between obesity and diabetes through fat cells.
Studies have shown that obesity affects the body’s production of vital cellular building blocks ribosomal factors, rendering the body’s fat cells unable to function properly. As a result, excess energy is stored in the body, which can lead to type 2 diabetes and other chronic diseases.
effect of obesity
In this research, the University of California-Los Angeles team proved for the first time that obesity affects the production of ribosomal factors in the body. Ribosomal factors are essential for cells and their deficiency prevents fat stem cells from producing functional fat cells. This problem occurs when there are not enough ribosomal factors in the body, due to which the size of fat cells starts increasing and the body’s energy remains trapped. This energy accumulates and causes problems in the body, such as the development of type 2 diabetes.
obesity problem
Dr. Claudio Villanueva, leader of the study, says that fat tissue is often considered harmful to our health, but it plays an important role in controlling blood sugar levels in the body. He says that obese people have high amount of fat tissue, which does not function properly, due to which the metabolism and energy storage capacity of the body reduces. This condition becomes more serious when fat stem cells do not function properly, causing energy to be stored elsewhere in the body. This stored excess energy can cause problems like fatty liver disease in the liver and atherosclerosis or stroke in the heart.
experiments done on rats
Obese and diabetic rats were used in this study. The fat cells of these mice were four to five times larger than those of lean mice. Then these rats were given a drug called Rosiglitazone. As a result, levels of ribosomal factors returned to normal in the mice, enabling their fat stem cells to create new and smaller fat cells. Subsequently, the mice’s fat tissue became better able to store energy, and it also began producing key hormones that regulate metabolism. Although the mice remained obese after taking the drug, their type 2 diabetes completely disappeared.
new treatment indications
This research indicates that understanding the complex relationship between obesity and type 2 diabetes may help, and may also aid in the development of new treatments. Scientists believe that these types of discoveries could open new avenues for treating type 2 diabetes and other chronic diseases.